Domus de Maria is a comune (municipality) in the Province of Cagliari in the Italian region Sardinia, located about 35 km southwest of Cagliari. As of 31 December 2004, it had a population of 1,579 and an area of 96.6 km².
The municipality of Domus de Maria contains the frazioni (subdivisions, mainly villages and hamlets) Chia, Eden Rock, and Setti Ballas.
Domus de Maria borders the following municipalities: Pula, Santadi, Teulada.